Enpp-1-IN-11

Enpp-1-IN-11 (compound 23) is a potent Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor with an Ki value of 45 nM. Enpp-1-IN-11 exhibits low clearance in human and mouse liver microsomes, good plasma stability in human and mouse plasma. Enpp-1-IN-11 can be used for researching anticancer[1].

Product Specifications

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/enpp-1-in-11.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(NC(CSC2=NC(N)=CC3=C2NC=N3)=O)=CC=C1O

Molecular Formula

C15H15N5O3S

Molecular Weight

345.38

References & Citations

[1]Gangar M, et al. Design, synthesis and biological evaluation studies of novel small molecule ENPP1 inhibitors for cancer immunotherapy. Bioorg Chem. 2022 Feb;119:105549.