CEase-IN-1

CEase-IN-1 (Compound A1H3) is a potent and selective cholesterol esterase (CEase) inhibitor with an IC50 of 0.36 μM. CEase-IN-1 can be used for the research of hypercholesterolemia[1].

Product Specifications

CAS Number

[2985688-68-2]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cease-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(COC1=CC=C(C(F)(F)F)C=C1)N/N=C/CCC

Molecular Formula

C13H15F3N2O2

Molecular Weight

288.27

References & Citations

[1]Zhao S, et al. Identification and synthesis of selective cholesterol esterase inhibitor using dynamic combinatorial chemistry. Bioorg Chem. 2022 Feb;119:105520.