Tubulin inhibitor 13
Tubulin inhibitor 13 (E27) is a potent tubulin inhibitor with an IC50 value of 16.1 μM for the tubulin polymerization inhibition. Tubulin inhibitor 13 inhibits migration and invasion of cancer cells, induces apoptosis and has anticancer activity[1].
Product Specifications
CAS Number
2883436-66-4
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-inhibitor-13.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C2N=C(C=C(C2=C1)C(N(CC3=NC=CC=C3)C)=O)C4=CC=C5OCOC5=C4
Molecular Formula
C25H21N3O4
Molecular Weight
427.45
References & Citations
[1]Wei Liu, et al. Discovery of novel tubulin inhibitors targeting the colchicine binding site via virtual screening, structural optimization and antitumor evaluation. Bioorg Chem. 2022 Jan;118:105486.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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