EGFR kinase inhibitor 1
Product Specifications
UNSPSC Description
EGFR kinase inhibitor 1 is a potent EGFR inhibitor with IC50s of 37, 1.7, >300 nM for WT, l885R/T790M, L858R/T790M/C797S, respectively. EGFR kinase inhibitor 1 induces apoptosis and cell cycle arrest at G0/G1-phase. EGFR kinase inhibitor 1 inhibits the cell motility. EGFR kinase inhibitor 1 shows antiproliferative and anti-tumor activity[1].
Target Antigen
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-kinase-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
C=CC(NC1=C(C=C(C(NC2=NC(C3=CN(C4=C3C=CC=C4)C)=CC=N2)=C1)OC)N5C=CC=C5CN(C)C)=O
Molecular Weight
521.61
References & Citations
[1]Ding S, et al. Design, synthesis and biological evaluation of novel N-(3-amino-4-methoxyphenyl)acrylamide derivatives as selective EGFRL858R/T790M kinase inhibitors. Bioorg Chem. 2022 Jan;118:105471.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143246/EGFR-kinase-inhibitor-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143246/
Clinical Information
No Development Reported
CAS Number
2413958-04-8
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