ATX inhibitor 11

ATX inhibitor 11 (compound 13c) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.7 nM. ATX inhibitor 11 can typically alleviate the severity of fibrosis tissues and effectively reduce the deposition of fibrotic biomarker α-SMA in mice fibrosis model. ATX inhibitor 11 can be used for lung fibrosis research[1].

Product Specifications

CAS Number

[2485779-27-7]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/atx-inhibitor-11.html

Purity

99.44

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCC1=C(N2C=C(C=C(C2=N1)C)C3=CC=C(C=C3)C(N4CCN(CC4)CCO)=O)NC(OCC5=CC6=C(OCO6)C=C5)=O

Molecular Formula

C32H35N5O6

Molecular Weight

585.65

References & Citations

[1]Lei H, et al. Novel imidazo[1,2-a]pyridine derivatives as potent ATX allosteric inhibitors: Design, synthesis and promising in vivo anti-fibrotic efficacy in mice lung model. Bioorg Chem. 2022 Mar;120:105590.