DHFR-IN-1
DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase) inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin , where the FIC (fractional inhibitory concentration index) value is 0.249[1].
Product Specifications
CAS Number
2757991-65-2
UNSPSC
12352005
Target
Bacterial; Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhfr-in-1.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(CC1)S(=O)(C2=CC=C3NC(/C(C3=C2)=N\NC4=NC(C5=CC=C(C=C5)O)=CS4)=O)=O
Molecular Formula
C22H22N6O4S2
Molecular Weight
498.58
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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