PIM-1/HDAC-IN-1

PIM-1/HDAC-IN-1 (compound 4d) is a PIM-1 inhibitor, with an IC50 of 343.87 nM. PIM-1/HDAC-IN-1 has strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC50 values of 63.65 and 62.39 nM, respectively. PIM-1/HDAC-IN-1 exhibits apoptosis inducing potential in MCF-7 cell lines. PIM-1/HDAC-IN-1 shows pre-G1 apoptosis and cell cycle arrest at G2/M phase[1].

Product Specifications

CAS Number

[2897622-19-2]

UNSPSC

12352005

Target

Apoptosis; HDAC; Pim

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pim-1-hdac-in-1.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(C=C(N=C1OCCCC(NO)=O)C2=CC=CC=C2)C3=CC=CC=C3

Molecular Formula

C22H19N3O3

Molecular Weight

373.40

References & Citations

[1]Bass AKA, et al. Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors. Bioorg Chem. 2022 Feb;119:105564.