NCGC00138783
NCGC00138783 is a selective inhibitor targeting CD47/SIRPα axis, with an IC50 of 50 µM. NCGC00138783 directly blocks the interaction between CD47 and SIRPα axis[1][2].
Product Specifications
UNSPSC
12352005
Target
CD47
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ncgc00138783.html
Solubility
10 mM in DMSO
Smiles
CCC(SC1=NC2=C(C=CC=C2)C3=NC(CCC4=C(C)NN=C4C)=NN13)C(NC5=CC=C(F)C=C5)=O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Molecular Formula
C30H28F7N7O5S
Molecular Weight
731.64
References & Citations
[1]Bo Huang, et al. Structural analysis and binding sites of inhibitors targeting the CD47/SIRPα interaction in anticancer therapy. Comput Struct Biotechnol J. 2021 Oct 1;19:5494-5503.|[2]Junqiao Zhu, et al. CD47-SIRPα axis in cancer therapy: Precise delivery of CD47-targeted therapeutics and design of anti-phagocytic drug delivery systems. Medicine in Drug Discovery. 2022. 15:100139
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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