Tebanicline

Tebanicline, an analogue of epibatidine, is a neuronal nicotinic acetylcholine receptor agonist. Tebanicline exhibits potent antinociceptive effects and has a high affinity for the α4β2 neuronal nicotinic acetylcholine receptor subunit in the central nervous system.

Product Specifications

CAS Number

198283-73-7

Product Name Alternative

Ebanicline; ABT-594

UNSPSC

12352005

Hazard Statement

H336

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tebanicline.html

Solubility

10 mM in DMSO

Smiles

ClC(C=C1)=NC=C1OC[C@@H]2NCC2

Molecular Formula

C9H11ClN2O

Molecular Weight

198.65

Precautions

P261-P271-P304+P340-P405-P501

References & Citations

[1]Donnelly-Roberts DL, et al. ABT-594 [ (R) -5- (2-azetidinylmethoxy) -2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.J Pharmacol Exp Ther. 1998 May;285 (2) :777-86.|[2]Bannon AW, et al. ABT-594 [ (R) -5- (2-azetidinylmethoxy) -2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization. J Pharmacol Exp Ther. 1998 May;285 (2) :787-94.|[3]Decker MW, et al. Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice. Eur J Pharmacol. 1998 Apr 3;346 (1) :23-33.|[4]Decker MW, et al. The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594. J Physiol Paris. 1998 Jun-Aug;92 (3-4) :221-4.|[5]Hayashi T, , et al. Antinociceptive effect of tebanicline for various noxious stimuli-induced behaviours in mice [J]. Neuroscience Letters, 2017, 638: 46-50.