BMS-582949
BMS-582949 (compound 7k) is an orally active and highly selective p38α MAP kinase inhibitor, with IC50 values of 13 nM for p38α, and 50 nM for cellular TNFα. BMS-582949 can be used for research on rheumatoid arthritis[1].
Product Specifications
CAS Number
[623152-17-0]
UNSPSC
12352005
Hazard Statement
H360-H373
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bms-582949.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCC)C1=CN(N=CN=C2NC3=CC(C(NC4CC4)=O)=CC=C3C)C2=C1C
Molecular Formula
C22H26N6O2
Molecular Weight
406.48
Precautions
P260-P280-P405-P501
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14305/BMS-582949-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14305/
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
P38α
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