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Vilanterol-d4 (trifenatate)

Vilanterol-d4 (trifenatate) is deuterium labeled Vilanterol (trifenatate) .Vilanterol (GW642444) acetate is a long-acting β2 adrenergic receptor agonist. Vilanterol acetate has pEC50 values for β2-AR, β1-AR, and β3-AR of 9.4, 6.4, and 6.1, respectively. Vilanterol acetate selectively activates airway β2 adrenergic receptors, increases cAMP and thus relaxes bronchial smooth muscle. Vilanterol acetate can be used in asthma research.

Product Specifications

CAS Number

2021249-10-3

Product Name Alternative

GW642444-d4 (trifenatate)

UNSPSC

12352005

Target

Adrenergic Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Endocrinology

Solubility

10 mM in DMSO

Smiles

OC(C(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O.ClC(C=CC=C4Cl)=C4COC([2H])([2H])C([2H])([2H])OCCCCCCNC[C@@H](C5=CC(CO)=C(C=C5)O)O

Molecular Formula

C44H45D4Cl2NO7

Molecular Weight

778.79

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Harrell AW, et al. Metabolism and disposition of Vilanterol, a long-acting β (2) -adrenoceptor agonist for inhalation use in humans. Drug Metab Dispos. 2013 Jan;41 (1) :89-100.|[3]Kempsford R, et al. Vilanterol trifenatate, a novel inhaled long-acting beta2 adrenoceptor agonist, is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD. Pulm Pharmacol Ther. 2013 Apr;26 (2) :256-|[4]Slack RJ, et al. In vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action. J Pharmacol Exp Ther. 2013 Jan;344 (1) :218-30

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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