1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine

1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine is a polyunsaturated phospholipid that is a constituent of lipid monolayers and small unilamellar vesicles. 1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine can be used to prepare endoplasmic reticulum-targeted liposomes (PERLs) in a molar ratio of 1.5:1.5:1:1 with 1,2-didocosahexaenoyl-sn-glycero-3-phosphoethanolamine, l-α-phosphatidylinositol, and l-α-phosphatidylserine. PERLs can reduce cholesterol levels in human peripheral blood mononuclear cells (PBMCs) and reduce HIV-1 particle secretion from HIV-1 infected PBMCs[1].

Product Specifications

CAS Number

[99296-81-8]

UNSPSC

12352200

Hazard Statement

H315, H319, H335, H360

Target

Liposome

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-2-didocosahexaenoyl-sn-glycero-3-phosphocholine.html

Concentration

11.39 mM * 100 μL in Chloroform

Purity

98.0

Solubility

10 mM in DMSO

Smiles

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O[C@H](COC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O

Molecular Formula

C52H80NO8P

Molecular Weight

878.17

Precautions

H315, H319, H335, H360

References & Citations

[1]Pollock S, et al. Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells. Proc Natl Acad Sci U S A. 2010 Oct 5;107 (40) :17176-81.