DOPG

Dioleoylphosphatidylglycerol (DOPG) is a naturally occurring phospholipid that can be produced by the combined action of aquaporin 3 (AQP3) and phospholipase D2 (PLD2) . Dioleoylphosphatidylglycerol inhibits macrophage inflammatory mediator production in response to heat shock protein B4 (HSPB4) activation of toll-like receptor 2 (TLR2) [1].

Product Specifications

CAS Number

62700-69-0

Product Name Alternative

Dioleoylphosphatidylglycerol

UNSPSC

12352200

Target

Liposome

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dioleoylphosphatidylglycerol.html

Solubility

10 mM in DMSO

Smiles

OCC(O)COP(OC[C@@H](COC(CCCCCCC/C=C\CCCCCCCC)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)(O)=O

Molecular Formula

C42H79O10P

Molecular Weight

775.04

References & Citations

[1]Chang L, et al. Low-dose dioleoylphosphatidylglycerol (DOPG) inhibits heat shock protein B4 (HSPB4) -induced activation of toll-like receptor 2 (TLR2) in a reporter cell line. Investigative Ophthalmology & Visual Science, 2020, 61 (7) : 357-357.