19 (S) -HETE

19 (S) -HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19 (S) -HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19 (S) -HETE inhibits platelet activation and relaxation of vessels[1].

Product Specifications

CAS Number

115461-40-0

UNSPSC

12352211

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/19-s-hete.html

Solubility

10 mM in DMSO

Smiles

C[C@H](O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O

Molecular Formula

C20H32O3

Molecular Weight

320.47

References & Citations

[1]Tunaru S, et al. Arachidonic Acid Metabolite 19 (S) -HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor. PLoS One. 2016 Sep 23;11 (9) :e0163633.