NaPi2b-IN-1
NaPi2b-IN-1 is a potent and orally active inhibitor of sodium-dependent phosphate transport protein 2b (NaPi2b) with an IC50 of 64 nM. NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. NaPi2b-IN-1 has the potential for the research of hyperphosphatemia[1].
Product Specifications
CAS Number
1453116-06-7
UNSPSC
12352005
Target
Sodium Channel; Sodium Phosphate Cotransporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/napi2b-in-1.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C(C=C1/C=N/NC(C2=C(NC(C3=CC(COCCOCCOCCOCCOCCOCCN(CC(O)=O)CCOC)=CC=C3)=O)SC4=C2CCC(C)(C)C4)=O)=C(C=C1)Cl
Molecular Formula
C44H58ClF3N4O11S
Molecular Weight
943.46
References & Citations
[1]Maemoto M, et al. Discovery of Gut-Restricted Small-Molecule Inhibitors of Intestinal Sodium-Dependent Phosphate Transport Protein 2b (NaPi2b) for the Treatment of Hyperphosphatemia. J Med Chem. 2022;65 (3) :1946-1960.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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