UNC6212 (Kme2)
Product Specifications
UNSPSC Description
UNC6212 (Kme2), a dimethyllysine (Kme2)-containing ligand, has a KD for CBX5 of 5.7 μM[1].
Target Antigen
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc6212-kme2.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=COC=C1)NC(C(N[C@@H](C)C(N[C@@H](CC2=CC=C(C(OC)=C2)OC)C(N[C@H](C(N[C@H](C(N)=O)CO)=O)CCCCN(C)C)=O)=O)=O)C(C3=CC=CC=C3)O
Molecular Weight
795.88
References & Citations
[1]Kean KM, et al. Systematic Variation of Both the Aromatic Cage and Dialkyllysine via GCE-SAR Reveal Mechanistic Insights in CBX5 Reader Protein Binding. J Med Chem. 2022;65(3):2646-2655.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-142954/UNC6212-Kme2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-142954/
Clinical Information
No Development Reported
Curated Selection
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