UNC6864 (Kei)

UNC6864 (Kei), an ethylisopropyllysine (Kei) -containing ligand, binds to wild-type CBX5, with a KD of 3.3 μM[1].

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/unc6864-kei.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=COC=C1)NC(C(N[C@@H](C)C(N[C@@H](CC2=CC=C(C(OC)=C2)OC)C(N[C@H](C(N[C@H](C(N)=O)CO)=O)CCCCN(CC)C(C)C)=O)=O)=O)C(C3=CC=CC=C3)O

Molecular Formula

C42H59N7O11

Molecular Weight

837.96

References & Citations

[1]Kean KM, et al. Systematic Variation of Both the Aromatic Cage and Dialkyllysine via GCE-SAR Reveal Mechanistic Insights in CBX5 Reader Protein Binding. J Med Chem. 2022;65 (3) :2646-2655.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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