UNC6864 (Kei)
UNC6864 (Kei), an ethylisopropyllysine (Kei) -containing ligand, binds to wild-type CBX5, with a KD of 3.3 μM[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc6864-kei.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=COC=C1)NC(C(N[C@@H](C)C(N[C@@H](CC2=CC=C(C(OC)=C2)OC)C(N[C@H](C(N[C@H](C(N)=O)CO)=O)CCCCN(CC)C(C)C)=O)=O)=O)C(C3=CC=CC=C3)O
Molecular Formula
C42H59N7O11
Molecular Weight
837.96
References & Citations
[1]Kean KM, et al. Systematic Variation of Both the Aromatic Cage and Dialkyllysine via GCE-SAR Reveal Mechanistic Insights in CBX5 Reader Protein Binding. J Med Chem. 2022;65 (3) :2646-2655.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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