KRAS G12C inhibitor 44
KRAS G12C inhibitor 44 (compound 54) is a potent and orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 shows anti-proliferation activities with IC50s of 0.016, 0.028 µM in MIA PaCA-2, H358 cells, respectively. KRAS G12C inhibitor 44 shows antitumor effects in vivo[1].
Product Specifications
CAS Number
2927439-07-2
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12c-inhibitor-44.html
Solubility
10 mM in DMSO
Smiles
ClC1=C2C([C@]3(CC2)CC4=NC(OC[C@H]5N(CCC5)C)=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C4CC3)=CC=C1
Molecular Formula
C31H36ClFN6O2
Molecular Weight
579.11
References & Citations
[1]Li Chao, et al. Spirocyclic tetrahydroquinazolines. WO2021139748A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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