KRAS G12C inhibitor 43
KRAS G12C inhibitor 43 (compound 59) is a potent KRAS G12C inhibitor. KRAS G12C inhibitor 43 shows antimigration and anti-proliferative activity with IC50s of 0.001-1 µM, >1 µM, >1 µM for H358, A549, HCC cells , respectively[1].
Product Specifications
CAS Number
[2648808-69-7]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12c-inhibitor-43.html
Solubility
10 mM in DMSO
Smiles
C=CC(N1CCN(C[C@@H]1CC#N)C2=C3C=CC(C4=C5C=CC=CC5=CC(OC)=C4)=NC3=NC(OC[C@@H]6CCCN6C)=N2)=O
Molecular Formula
C33H35N7O3
Molecular Weight
577.68
References & Citations
[1]Xu Wei, et al. Pyridopyrimidine kras g12c mutant protein inhibitor. WO2021139678A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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