Glucocorticoid receptor-IN-1
Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC50 of 2.11 nM against hMMP1, and transcriptional activation activity with an EC50 of 5.59 nM against MMTV[1].
Product Specifications
CAS Number
2662908-25-8
UNSPSC
12352005
Target
Glucocorticoid Receptor; MMP
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/glucocorticoid-receptor-in-1.html
Solubility
10 mM in DMSO
Smiles
CC(F)(F)C(N[C@@H](C)[C@@H](C1=CC(F)=CC(F)=C1)OC2=CC=C(N(C3=CN4C(C=C3)=NN=C4)N=N5)C5=C2)=O
Molecular Formula
C24H19F4N7O2
Molecular Weight
513.45
References & Citations
[1]Guoli Zhang, et al. Benzo[d][1,2,3]triazole ether compound. WO2021136431.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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