RORγt agonist 2
Product Specifications
UNSPSC Description
RORγt agonist 2 is a potent agonist of RORγt. RORγt agonist 2 promotes the differentiation of Th17 cells and enhances the levels of pro-inflammatory cytokines, thereby increasing the cytotoxicity of lymphocytes. RORγt agonist 2 inhibits the production of regulatory T cells, which suppresses the immune response (extracted from patent WO2021136339A1, compound 17)[1].
Target Antigen
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-agonist-2.html
Solubility
10 mM in DMSO
Smiles
CC(C1N(C2=CC=C(C=C2)C(F)(F)F)C3=CC=C(C(N[C@H](C4=CC=C(C=C4)S(CC)(=O)=O)CC#N)=O)C=C3OC1)C
Molecular Weight
585.64
References & Citations
[1]Liu Bin, et al. Amides with bicyclic structures and their applications in pharmaceuticals. Patent WO2021136339A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-142937/RORγt-agonist-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-142937/
Clinical Information
No Development Reported
CAS Number
2663787-92-4
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