BCR-ABL-IN-4
BCR-ABL-IN-4 is a BCR-ABL inhibitor with anticancer effects. BCR-ABL-IN-4 inhibits the cancer cell growth with IC50 values of 0.67 nM and 16 nM for K562 cells and BCR-ABL T315I transfected Ba/F3 cells, respectively (WO2021143927A1; compound 11) [1].
Product Specifications
CAS Number
2669790-59-2
UNSPSC
12352005
Target
Bcr-Abl
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcr-abl-in-4.html
Solubility
10 mM in DMSO
Smiles
ClC(F)(F)OC(C=C1)=CC=C1NC(C2=CC(C3=CN=C(CN(C4CC4)C5=O)C5=C3)=C(N6C[C@@H](CC6)O)N=C2)=O
Molecular Formula
C27H24ClF2N5O4
Molecular Weight
555.96
References & Citations
[1]Yinsheng Zhang, et al. Compound acting as bcr-abl inhibitor. WO2021143927A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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