RORγt/DHODH-IN-1
Product Specifications
UNSPSC Description
RORγt/DHODH-IN-1 (compound (R)-14d) is a potent and orally active dual RORγt/DHODH inhibitor, with IC50s of 0.083 μM and 0.172 μM, respectively. RORγt/DHODH-IN-1 exhibits remarkable in vivo anti-inflammatory activity[1].
Target Antigen
Dihydroorotate Dehydrogenase; ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-dhodh-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C=C(C=C1NC2=NC3=C(S2)CCC[C@H]3O)Cl)OC4CCN(CC4)C(CC(C(F)(F)F)C(F)(F)F)=O
Molecular Weight
585.99
References & Citations
[1]Chen J, et, al. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J Med Chem. 2022 Jan 13;65(1):592-615.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-142843/RORγt-DHODH-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-142843/
Clinical Information
No Development Reported
CAS Number
2764662-15-7
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