RORγt/DHODH-IN-1

RORγt/DHODH-IN-1 (compound (R) -14d) is a potent and orally active dual RORγt/DHODH inhibitor, with IC50s of 0.083 μM and 0.172 μM, respectively. RORγt/DHODH-IN-1 exhibits remarkable in vivo anti-inflammatory activity[1].

Product Specifications

CAS Number

[2764662-15-7]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rorγt-dhodh-in-1.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C=C(C=C1NC2=NC3=C(S2)CCC[C@H]3O)Cl)OC4CCN(CC4)C(CC(C(F)(F)F)C(F)(F)F)=O

Molecular Formula

C24H26ClF6N3O3S

Molecular Weight

585.99

References & Citations

[1]Chen J, et, al. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J Med Chem. 2022 Jan 13;65 (1) :592-615.