RORγt inverse agonist 26
RORγt inverse agonist 26 is a potent reverse agonist of RORγt. RORγt inverse agonist 26 regulates the differentiation of Th17 cells and inhibits the production of IL-17. RORγt inverse agonist 26 has the potential for the research of inflammation and autoimmune diseases (extracted from patent WO2021228215A1, compound 1) [1].
Product Specifications
CAS Number
[2738333-10-1]
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-inverse-agonist-26.html
Solubility
10 mM in DMSO
Smiles
FC(C=C(C=C1)C(C(F)(F)F)(O)C(F)(F)F)=C1C(C=C2)=CC=C2NC([C@H]3C4=CC=C(S(C)(=O)=O)C=C4CN3C(C)=O)=O
Molecular Formula
C27H21F7N2O5S
Molecular Weight
618.52
References & Citations
[1]Yaobang Chen, et al. Biaryls as RORγ Modulators. Patent WO2021228215A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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