Y08284

Y08284 is a potent, selective, oral active CBP bromodomain inhibitor with an IC50 of 4.21 nM. Y08284 suppresses the proliferation of prostate cancer cell lines LNCaP, C4-2B, and 22Rv1. Antitumor activity[1].

Product Specifications

CAS Number

[2688745-47-1]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/y08284.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2C=C(OC)C=CN2C(C(C)=O)=C1)NC3=CC(C(O)C)=CC(C4=CN(C5CC5)N=C4)=C3F

Molecular Formula

C26H25FN4O4

Molecular Weight

476.50

References & Citations

[1]Xiang Q, et al. Design, Synthesis, and Biological Evaluation of 1- (Indolizin-3-yl) ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer. J Med Chem. 2022;65 (1) :785-810.