Y08284
Y08284 is a potent, selective, oral active CBP bromodomain inhibitor with an IC50 of 4.21 nM. Y08284 suppresses the proliferation of prostate cancer cell lines LNCaP, C4-2B, and 22Rv1. Antitumor activity[1].
Product Specifications
CAS Number
[2688745-47-1]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/y08284.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2C=C(OC)C=CN2C(C(C)=O)=C1)NC3=CC(C(O)C)=CC(C4=CN(C5CC5)N=C4)=C3F
Molecular Formula
C26H25FN4O4
Molecular Weight
476.50
References & Citations
[1]Xiang Q, et al. Design, Synthesis, and Biological Evaluation of 1- (Indolizin-3-yl) ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer. J Med Chem. 2022;65 (1) :785-810.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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