Levocabastine

Levocabastine (R 50547) is a potent and selective histamine H1-receptor antagonist. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2. Levocabastine can act as a VLA-4 antagonist, interferes with conjunctival eosinophil infiltration in allergic conjunctivitis (AC) [1][2][3].

Product Specifications

CAS Number

[79516-68-0]

Product Name Alternative

R 50547

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Histamine Receptor; Integrin; Neurotensin Receptor

Type

Reference compound

Related Pathways

Cytoskeleton; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/levocabastine.html

Solubility

10 mM in DMSO

Smiles

OC([C@@]1(C2=CC=CC=C2)[C@@H](CN([C@]3([H])CC[C@](CC3)(C4=CC=C(C=C4)F)C#N)CC1)C)=O

Molecular Formula

C26H29FN2O2

Molecular Weight

420.52

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Folkerts G, et, al. Virus-induced airway hyperresponsiveness in the guinea-pig: possible involvement of histamine and inflammatory cells. Br J Pharmacol. 1993 Apr;108 (4) :1083-93.|[2]Yamauchi R, et, al. Effect of beta-lactotensin on acute stress and fear memory. Peptides. 2006 Dec;27 (12) :3176-82.|[3]Qasem AR, et, al. Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine. Biochem Pharmacol. 2008 Sep 15;76 (6) :751-62.