Anastrozole-d12

Anastrozole-d12 is the deuterium labeled Anastrozole. Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM[1][2].

Product Specifications

CAS Number

[120512-32-5]

Product Name Alternative

ZD1033-d12

UNSPSC

12352005

Hazard Statement

H302, H360

Target

Cytochrome P450; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Purity

99.74

Solubility

10 mM in DMSO

Smiles

N#CC(C([2H])([2H])[2H])(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C#N)=CC(CN2C=NC=N2)=C1)C([2H])([2H])[2H]

Molecular Formula

C17H7D12N5

Molecular Weight

305.44

Precautions

H302, H360

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Dukes M, et al. The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033) --a potent, selective aromatase inhibitor. J Steroid Biochem Mol Biol. 1996 Jul;58 (4) :439-45.