KCa2 channel modulator 2
KCa2 channel modulator 2 (compound 2q) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 2 exhibits similar potency on the rat KCa2.2a and human KCa2.3 channel subtypes, with EC50s of 0.64 μM and 0.60 μM, respectively[1]
Product Specifications
CAS Number
2764618-34-8
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kca2-channel-modulator-2.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(NC2=C(C=CC(Cl)=C2)F)=NC(N3C(C)=CC(C)=N3)=N1
Molecular Formula
C16H15ClFN5
Molecular Weight
331.78
References & Citations
[1]El-Sayed NS, et al. Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels. J Med Chem. 2022;65 (1) :303-322.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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