KCa2 channel modulator 1
KCa2 channel modulator 1 (compound 2o) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 1 potentiates human KCa2.3 channels with an EC50 value of 0.19 μM and 0.99 μM on the rat KCa2.2 channel subtype[1].
Product Specifications
CAS Number
1019106-73-0
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kca2-channel-modulator-1.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(NC2=CC=C(F)C(Cl)=C2)=NC(N3N=C(C)C=C3C)=N1
Molecular Formula
C16H15ClFN5
Molecular Weight
331.78
References & Citations
[1]El-Sayed NS, et al. Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels. J Med Chem. 2022;65 (1) :303-322.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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