Acreozast

Acreozast (TYB-2285) is a histamine release inhibitor. Acreozast inhibits the histamine release primed with IL-3. Acreozast might regulate allergic inflammation in vivo by the suppression of mediator release primed with IL-3[1].

Product Specifications

CAS Number

[123548-56-1]

Product Name Alternative

TYB-2285

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/acreozast.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=C(C(NC(COC(C)=O)=O)=CC(C#N)=C1)Cl)COC(C)=O

Molecular Formula

C15H14ClN3O6

Molecular Weight

367.74

References & Citations

[1]Watanabe A, et al. Effect of TYB-2285 on antigen-induced histamine release from mouse bone marrow-derived persisting cells (P-cells) primed with interleukin-3-containing conditioned medium (IL3-CM) . Gen Pharmacol. 1993 Sep;24 (5) :1207-11.