RORγt inverse agonist 28
RORγt inverse agonist 28 is a potent reverse agonist of RORγt. RORγt inverse agonist 28 regulates the differentiation of Th17 cells and inhibits the production of IL-17. RORγt inverse agonist 28 has the potential for the research of inflammation and autoimmune diseases (extracted from patent WO2021228215A1, compound 6) [1].
Product Specifications
CAS Number
2741870-21-1
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-inverse-agonist-28.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)OC1=C(C2=C(C=C(C=C2Cl)NC([C@H](C3=CC=C(C=C3)S(C)(=O)=O)CO)=O)Cl)C=CC=C1
Molecular Formula
C23H18Cl2F3NO5S
Molecular Weight
548.36
References & Citations
[1]Yaobang Chen, et al. Biaryls as RORγ Modulators. Patent WO2021228215A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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