SGC agonist 2
SGC agonist 2 is a potent agonist of soluble guanylate cyclase (SGC) . Soluble guanylate cyclase is a key signal transduction enzyme in the NO-sGC-cGMP signaling pathway. SGC agonist 2 has the potential for the research of cardiovascular disease (heart failure, pulmonary hypertension, angina, myocardial infarction) and fibrotic diseases (renal fibrosis, systemic sclerosis) (extracted from patent WO2021219088A1, compound 031) [1].
Product Specifications
CAS Number
[2735713-77-4]
UNSPSC
12352005
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sgc-agonist-2.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@]2([H])C3=C(N1)NC(C(C4=C5)=NN(CC6=C(C=CC=C6)F)C4=NC=C5F)=NC3=NC(C2(C)C)=O
Molecular Formula
C23H17F2N7O2
Molecular Weight
461.42
References & Citations
[1]Fuyu Luo, et al. Pyrimidine tricyclic compounds and their applications. Patent WO2021219088A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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