DCN1-UBC12-IN-2
DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor (IC50=9.55 nM) . DCN1-UBC12-IN-2 could specifically target DCN1-UBC12 interaction and relieve Ang II-induced cardiac fibroblast activation[1].
Product Specifications
CAS Number
2374827-47-9
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dcn1-ubc12-in-2.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(C2=CC(OC)=C(OC)C(OC)=C2)N=C(SCC3=CC=C(Cl)C=C3)N=C1SC4=NN=NN4C
Molecular Formula
C23H20ClN7O3S2
Molecular Weight
542.03
References & Citations
[1]He ZX, et al. Discovery of Potent and Selective 2- (Benzylthio) pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem. 2022;65 (1) :163-190.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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