EGFR-IN-22
Product Specifications
UNSPSC Description
EGFR-IN-22 is a potent EGFR inhibitor with IC50s of 4.91 nM and 0.54 nM for wild type EGFR and EGFRL858R/T790M/C797S, respectively (CN112538072A, compound 243)[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-22.html
Solubility
10 mM in DMSO
Smiles
O=P(C)(C)C1=C2N=CC=NC2=CC=C1NC3=NC(NC4=C(OC)C=C(N5CCC6(CCN(C(C)(CF)C)CC6)CC5)C(C7=CN(C)N=C7)=C4)=NC=C3Br
Molecular Weight
805.72
References & Citations
[1]EGFR-IN-22 is a potent <b>EGFR</b> inhibitor with IC50 of 4.91 nM and 0.54 nM for <b>wild type EGFR</b> and <b>EGFR<sup>L858R/T790M/C797S</sup></b>, respectively (CN112538072A, compound 243)<sup>[1]</sup>.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-142679/EGFR-IN-22-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-142679/
Clinical Information
No Development Reported
CAS Number
2634646-14-1
Curated Selection
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