ATR-IN-5
ATR-IN-5 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-5 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent CN112047938A, compound D24) [1].
Product Specifications
CAS Number
2601571-19-9
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atr-in-5.html
Solubility
10 mM in DMSO
Smiles
CNC1=NC2=CC=CC=C2N1C3=NC(N4[C@@H](COCC4)C)=CC(C5=C(N(C6CCNCC6)N=C5C)C(F)(F)F)=N3
Molecular Formula
C27H32F3N9O
Molecular Weight
555.60
References & Citations
[1]Zhao, Yanping, et al. 2,4,6-Trisubstituted pyrimidine compounds as atr kinase inhibitors. Patent CN112047938A.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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