Lp-PLA2-IN-4
Lp-PLA2-IN-4 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) . Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-4 has the potential for the research of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease (extracted from patent WO2021228159A1, compound 38) [1].
Product Specifications
CAS Number
2738877-91-1
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lp-pla2-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C1N2C(N3C[C@@H](OCC3)C2)=CC(OCC4=CC(F)=C(C(F)=C4)OC5=CC(C(F)(F)F)=CC=C5)=N1
Molecular Formula
C23H18F5N3O4
Molecular Weight
495.40
References & Citations
[1]Zhenhua Gu, et al. Bridging cyclic pyrimidinones, methods of preparation thereof, compositions thereof and uses. Patent WO2021228159A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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