Lp-PLA2-IN-4
Product Specifications
UNSPSC Description
Lp-PLA2-IN-4 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-4 has the potential for the research of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease (extracted from patent WO2021228159A1, compound 38)[1].
Target Antigen
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lp-pla2-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C1N2C(N3C[C@@H](OCC3)C2)=CC(OCC4=CC(F)=C(C(F)=C4)OC5=CC(C(F)(F)F)=CC=C5)=N1
Molecular Weight
495.40
References & Citations
[1]Zhenhua Gu, et al. Bridging cyclic pyrimidinones, methods of preparation thereof, compositions thereof and uses. Patent WO2021228159A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-142669/Lp-PLA2-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-142669/
Clinical Information
No Development Reported
CAS Number
2738877-91-1
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