IRE1α kinase-IN-6
IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC50 value of 4.4 nM.
Product Specifications
CAS Number
2715123-88-7
UNSPSC
12352005
Target
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ire1α-kinase-in-6.html
Solubility
10 mM in DMSO
Smiles
FC(C(NS(=O)(C1=C(C=CC=C1)Cl)=O)=CC=C2Cl)=C2NC(C3=CSC(C3=NC=N4)=C4N[C@H]5CC[C@@H](CC5)N)=O
Molecular Formula
C25H23Cl2FN6O3S2
Molecular Weight
609.52
References & Citations
[1]Beveridge RE, et al. Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity. ACS Med Chem Lett. 2020 Oct 16;11 (12) :2389-2396.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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