(R) -MLT-985
(R) -MLT-985 is the R configuration of MLT-985. MLT-985 is a selective allosteric and orally active MALT1 inhibitor with an IC50 value of 3 nM. MLT-985 can suppress cell growth and aberrant CARD11/BCL10/MALT1 complex signaling. MLT-985 can be used for the research of cancer, such as B cell malignancies[1][2].
Product Specifications
CAS Number
1832577-07-7
UNSPSC
12352005
Target
MALT1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-mlt-985.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC(Cl)=C(N2N=CC=N2)N=C1)NC3=C([C@H](OC)C)N4C(N=C3)=CC(Cl)=N4
Molecular Formula
C17H15Cl2N9O2
Molecular Weight
448.27
References & Citations
[1]Quancard J, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63 (23) :14594-14608.|[2]Sara Elgamal, et al. Development of ZE66-0205, a Novel MALT1 Degrader for Treatment of B-Cell Malignancies, Blood, Volume 144, Supplement 1, 2024, Page 2783, ISSN 0006-4971.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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