TP0591816

TP0591816 is a potent dual inhibitor of wild-type and mutant respiratory syncytial virus fusion proteins (wild-type, EC50 = 0.27 nM; D486N-mutant, EC50 = 0.70 nM) .

Product Specifications

CAS Number

[2448519-26-2]

UNSPSC

12352005

Target

RSV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/tp0591816.html

Solubility

10 mM in DMSO

Smiles

CN1C2=CC([C@]3([H])C[C@H](C3)O)=NC4=CC([C@@]5([H])N(CCCC5)C(C6=CC(Cl)=CC=C6OCC(NCC1)=O)=O)=NN24

Molecular Formula

C27H31ClN6O4

Molecular Weight

539.03

References & Citations

[1]Yamaguchi-Sasaki T, et al. Discovery of a potent dual inhibitor of wild-type and mutant respiratory syncytial virus fusion proteins through the modulation of atropisomer interconversion properties. Bioorg Med Chem. 2020 Dec 15;28 (24) :115818.