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BCPyr

BCPyr is a PROTAC-class BTK degrader (DC50 = 800 nM) [1]. BCPyr consists of a PROTAC target protein ligand (red part) BTK ligand 11 (HY-168314), an E3 ubiquitin ligase ligand (blue part) E3 ligase Ligand 20 (HY-135997), and a PROTAC linker (black part) (5- (Bromomethyl) pyrazin-2-yl) methanol (HY-168315) . E3 ubiquitin ligase+linker can form E3 Ligase Ligand-linker Conjugate 146 (HY-168316) .

Product Specifications

CAS Number

[2669844-82-8]

UNSPSC

12352005

Target

Btk; PROTACs

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bcpyr.html

Solubility

10 mM in DMSO

Smiles

O=C(N1C[C@H](N2N=C(C3=CC=C(OC4=CC=C(F)C=C4F)C=C3)C(C(N)=O)=C2N)CCC1)OCC5=NC=C(COC6=CC7=C(C=C6)C[C@@H](C(N[C@@H]8CCCC9=C8C=CC=C9)=O)N(C([C@@H](NC([C@@H](NC)C)=O)C(C)(C)C)=O)C7)N=C5

Molecular Formula

C58H65F2N11O8

Molecular Weight

1082.20

References & Citations

[1]Schiemer J, et al. Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes. Nat Chem Biol. 2021 Feb;17 (2) :152-160.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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