BCPyr
BCPyr is a PROTAC-class BTK degrader (DC50 = 800 nM) [1]. BCPyr consists of a PROTAC target protein ligand (red part) BTK ligand 11 (HY-168314), an E3 ubiquitin ligase ligand (blue part) E3 ligase Ligand 20 (HY-135997), and a PROTAC linker (black part) (5- (Bromomethyl) pyrazin-2-yl) methanol (HY-168315) . E3 ubiquitin ligase+linker can form E3 Ligase Ligand-linker Conjugate 146 (HY-168316) .
Product Specifications
CAS Number
[2669844-82-8]
UNSPSC
12352005
Target
Btk; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcpyr.html
Solubility
10 mM in DMSO
Smiles
Molecular Formula
C58H65F2N11O8
Molecular Weight
1082.20
References & Citations
[1]Schiemer J, et al. Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes. Nat Chem Biol. 2021 Feb;17 (2) :152-160.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-142621/BCPyr-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-142621/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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