TP0586352

TP0586352 is a LpxC inhibitor that is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk. TP0586352 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2427626-11-5]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/tp0586352.html

Solubility

10 mM in DMSO

Smiles

NC[C@@H](N1C([C@@H](O)C)=NC=C1)C2=NOC(C(C=C3)=CC=C3C#C[C@H]4[C@@]5([H])[C@]4([H])CN(C5)C[C@@H](O)C)=C2

Molecular Formula

C26H31N5O3

Molecular Weight

461.56

References & Citations

[1]Ushiyama F, et al. Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532. Bioorg Med Chem. 2021 Jan 15;30:115964.