Fadrozole (hydrochloride hemihydrate)
Fadrozole hydrochloride hemihydrate is an orally active, potent, selective and nonsteroidal aromatase inhibitor, with an IC50 of 6.4 nM. Fadrozole hydrochloride hemihydrate inhibits the production of estrogen and progesterone, with IC50 values of 0.03 and 120 μM. Fadrozole hydrochloride hemihydrate shows prevention of spontaneous tumours. Fadrozole hydrochloride hemihydrate can be used for the research of estrogen-dependent disease and cancer[1][2][3].
Product Specifications
CAS Number
176702-70-8
Product Name Alternative
CGS 16949A (hemihydrate) ; (Rac) -FAD286 (hydrochloride hemihydrate)
UNSPSC
12352005
Hazard Statement
H301+H311+H331, H315, H319
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/fadrozole-hydrochloride-hemihydrate.html
Purity
99.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(C=C1)C2CCCC3=CN=CN23.[H]Cl.[H]O[H].[1/2]
Molecular Formula
C14H13N3.ClH.1/2H2O
Molecular Weight
268.74
Precautions
H301+H311+H331, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Aromatase/CYP19A1
Available Sizes
Frequently Asked Questions
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