PG 116800

PG 116800 (PG 530742) is an orally avtive MMP inhibitor. PG 116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, while having substantially lower affinity for MMP-1 and -7. PG 116800 can be used for knee osteoarthritis research[1].

Product Specifications

CAS Number

[291533-11-4]

Product Name Alternative

PG 530742; PGE 530742; PGE 7113313

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pg-116800.html

Purity

99.81

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(C(NS(=O)(C1=CC=C(NC(C2=CC=C(OC)C=C2)=O)C=C1)=O)CC#CCN3CCOCC3)=O

Molecular Formula

C24H27N3O7S

Molecular Weight

501.55

References & Citations

[1]Piotr Krzeski, et al. Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study. Arthritis Res Ther. 2007;9 (5) :R109.