RORγt inhibitor 1

RORγt inhibitor 1 is a RORγt allosteric inhibitor with an IC50 value of 1 nM.

Product Specifications

CAS Number

[1561770-72-6]

UNSPSC

12352005

Target

ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rorγt-inhibitor-1.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H]1CCN(C[C@H]1O)C2=NN(C3=CC=CC(F)=C32)C(C4=C(C=CC=C4Cl)C5CC5)=O)O

Molecular Formula

C23H21ClFN3O4

Molecular Weight

457.88

References & Citations

[1]Zhang H, et al. Discovery of N- (Indazol-3-yl) piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases. ACS Med Chem Lett. 2020 Jan 9;11 (2) :114-119.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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