RORγt inhibitor 1
RORγt inhibitor 1 is a RORγt allosteric inhibitor with an IC50 value of 1 nM.
Product Specifications
CAS Number
[1561770-72-6]
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H]1CCN(C[C@H]1O)C2=NN(C3=CC=CC(F)=C32)C(C4=C(C=CC=C4Cl)C5CC5)=O)O
Molecular Formula
C23H21ClFN3O4
Molecular Weight
457.88
References & Citations
[1]Zhang H, et al. Discovery of N- (Indazol-3-yl) piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases. ACS Med Chem Lett. 2020 Jan 9;11 (2) :114-119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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