RORγt inhibitor 1
Product Specifications
UNSPSC Description
RORγt inhibitor 1 is a RORγt allosteric inhibitor with an IC50 value of 1 nM.
Target Antigen
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H]1CCN(C[C@H]1O)C2=NN(C3=CC=CC(F)=C32)C(C4=C(C=CC=C4Cl)C5CC5)=O)O
Molecular Weight
457.88
References & Citations
[1]Zhang H, et al. Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases. ACS Med Chem Lett. 2020 Jan 9;11(2):114-119.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-142296/RORγt-inhibitor-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-142296/
Clinical Information
No Development Reported
CAS Number
1561770-72-6
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