LIMK-IN-1
Product Specifications
UNSPSC Description
LIMK-IN-1 (Compound 14) is a LIMK1/2 inhibitor (IC50: 0.5 nM and 0.9 nM respectively). LIMK-IN-1 can be used for research of ocular hypertension and associated glaucoma[1].
Target Antigen
LIM Kinase (LIMK); ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/limk-in-1.html
Purity
99.33
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC1=CNC2=NC=NC(N3C[C@H](C)N(/C(NC4=CC=CC(Br)=C4)=N\C#N)CC3)=C21
Molecular Weight
453.34
References & Citations
[1]Harrison BA, et.al. Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8. |[2]Harrison BA, et al. Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14227/LIMK-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14227/LIMK-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1116571-01-7
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