Beauverolide Ka

Beauverolide Ka, a cyclotetradepsipeptide, is a metabolite of Beauveria bassiana fungus. Beauverolide Ka stimulates glucose uptake in cultured rat L6 myoblasts at 50 μM. Beauverolide Ka exhibits protecting effects on HEI-OC1 cells at 10 μM and shows dose-dependent activity in both L6 myoblasts and myotubes[1][2].

Product Specifications

CAS Number

[76265-42-4]

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/beauverolide-ka.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](C(O[C@@H](CC(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N3)=O)=O)[C@@H](C)CCCCCC)=O)[C@@H](C)CC)[C@@H]3CC4=CC=CC=C4

Molecular Formula

C37H50N4O5

Molecular Weight

630.82

References & Citations

[1]Yuan-Fei Zhou, et al. 3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp. J Nat Prod. 2021 Apr 23;84 (4) :1244-1253.|[2]Feifei Luo, et al. Differential metabolic responses of Beauveria bassiana cultured in pupae extracts, root exudates and its interactions with insect and plant. J Invertebr Pathol. 2015 Sep;130:154-64.