Lazabemide (hydrochloride)
Lazabemide hydrochloride (Ro 19-6327 hydrochloride) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM) . Lazabemide inhibits monoamine uptake at high concentrations, the IC50 values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease[1].
Product Specifications
CAS Number
103878-83-7
Product Name Alternative
Ro 19-6327 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lazabemide-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC=C(Cl)C=C1)NCCN.[H]Cl
Molecular Formula
C8H11Cl2N3O
Molecular Weight
236.10
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAO-B
Available Sizes
Frequently Asked Questions
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